P-10: Ethyl Pyrovate Repopulate The Leydig and Sertoli Cells in Testis of Cyclophosphamide Treated Adult Mice

P-74: Crocin Repopulate The Leydig and Sertoli Cells in Testis of Cyclophosphamide Treated Adult Mice

Background: Increases in the survival rate of men treated with chemotherapeutic drugs and their desire to have children precipitate concerns about the effects of these drugs on germ cells. This study performed to evaluation of protective effects of crocin in oxidative stress induced by cyclophosphamide (CP) on testis. Materials and Methods: Three groups (6 mice in each) of adult mice were used....

P-2: Protective Effects of Ethyl Pyruvate on Serum Antioxidant Capacity and Testis Germinalepithelium Morphometryin Cyclophosphamide Treated Mice

Background Cyclophosphamide (CP) is a chemotherapeuticdrug which causes deleterious effects on tissue of testicle and increases free radicals in the body. The aim of this study is to investigate protective effects of ethyl pyruvate (EP) on improvement of testicle inCP treated animals. MaterialsAndMethods In this study, 15 male mice(6-8 weeks) were divided into 3 groups. Control group receivedno...

Protective effect of ethyl pyruvate on testicular histology and fertilization potential in cyclophosphamide treated mice

In the present study, we aimed to address the use of ethyl pyruvate (EP) against the harmful effects of cyclophosphamide (CP) treatment. Thirty-nine adult male mice were divided into three groups including control group received normal saline [0.20 mL per day; intraperitoneally (IP)], CP group received CP (15.00 mg kg-1 per week, IP) and CP+EP group received EP (40.00 mg kg-1</s...

Sertoli Cells Maintain Leydig Cell Number and Peritubular Myoid Cell Activity in the Adult Mouse Testis

The Sertoli cells are critical regulators of testis differentiation and development. In the adult, however, their known function is restricted largely to maintenance of spermatogenesis. To determine whether the Sertoli cells regulate other aspects of adult testis biology we have used a novel transgenic mouse model in which Amh-Cre induces expression of the receptor for Diphtheria toxin (iDTR) s...

DHT Germ cells Genital crest Testis Leydig Sertoli

Sex differentiation is a process that starts early during embryogenesis. In males, the SRY gene, located in the short arm of chromosome Y, encodes for the testis-determining factor, which causes the gonad to differentiate into testis. Testicular androgen synthesis by Leydig cells starts from the eighth week of development. It is initially stimulated by placental chorionic gonadotropin (HCG), an...

Comparison of Neonatal and Adult Mice-derived Sertoli Cells in Support of Expansion of Mouse Spermatogonial Stem Cells In vitro